Journal of Clinical Anesthesia
Volume 21, Issue 6 , Pages 394-400 , September 2009

Results of a pilot study on the effects of propofol and dexmedetomidine on inflammatory responses and intraabdominal pressure in severe sepsis

  • Muhittin Tasdogan, MD (Staff Anesthesiologist)

      Affiliations

    • Department of Anaesthesiology and Reanimation, Trakya University Medical Faculty, 22030 Edirne, Turkey
  • ,
  • Dilek Memis, MD (Associate Professor of Anesthesia)

      Affiliations

    • Department of Anaesthesiology and Reanimation, Trakya University Medical Faculty, 22030 Edirne, Turkey
    • Corresponding Author InformationCorresponding author. Fax: +90 284 235 80 96.
  • ,
  • Necdet Sut (Assistant Professor of Biostatistics)

      Affiliations

    • Department of Biostatistics, Trakya University Medical Faculty, 22030 Edirne, Turkey
  • ,
  • Mahmut Yuksel, MD (Associate Professor of Nuclear Medicine)

      Affiliations

    • Department of Nuclear Medicine, Trakya University Medical Faculty, 22030 Edirne, Turkey

Received 14 May 2007 ,Revised 27 September 2008 ,Accepted 7 October 2008.

References 

  1. Bone RC. Gram-negative sepsis: a dilemma of modern medicine. Clin Microbial Rev. 1993;6:57–68
  2. The American College of Chest Physicians/Society of Critical Care Medicine Consensus Conference. Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. Crit Care Med. 1992;20:864–874
  3. Dyck JB, Shafer SL. Dexmedetomidine pharmacokinetics and pharmacodynamics. Anaesth Pharmacol Rev. 1993;1:238–245
  4. Taniguchi T, Kidani Y, Kanakura H, Takemoto Y, Yamamoto K. Effects of dexmedetomidine on mortality rate and inflammatory responses to endotoxin-induced shock in rats. Crit Care Med. 2004;32:1322–1326
  5. Rossano F, Tufano R, Cipollaro de L'Ero G, Servillo G, Baroni A, Tufano MA. Anesthetic agents induce human mononuclear leucocytes to release cytokines. Immunopharmacol Immunotoxicol. 1992;14:439–450
  6. Larsen B, Hoff G, Wilhelm W, Buchinger H, Wanner GA, Bauer M. Effect of intravenous anesthetics on spontaneous and endotoxin-stimulated cytokine response in cultured human whole blood. Anesthesiology. 1998;89:1218–1227
  7. Malbrain ML, Delaet I, Cheatham M. Consensus conference definitions and recommendations on intraabdominal hypertension (IAH) and the abdominal compartment syndrome (ACS)–the long road to the final publications, how did we get there?. Acta Clin Belg Suppl. 2007;1:44–59
  8. Malbrain ML, Chiumello D, Pelosi P, et al. Prevalence of intraabdominal hypertension in critically ill patients: a multicentre epidemiological study. Intensive Care Med. 2004;30:822–829
  9. Malbrain ML, Chiumello D, Pelosi P, et al. Incidence and prognosis of intraabdominal hypertension in a mixed population of critically ill patients: a multiple-center epidemiological study. Crit Care Med. 2005;33:315–322
  10. Malbrain ML, Cheatham ML, Kirkpatrick A, et al. Results from the International Conference of Experts on Intraabdominal Hypertension and Abdominal Compartment Syndrome. I. Definitions. Intensive Care Med. 2006;32:1722–1732
  11. Cheatham ML, Malbrain ML, Kirkpatrick A, et al. Results from the International Conference of Experts on Intraabdominal Hypertension and Abdominal Compartment Syndrome. II. Recommendations. Intensive Care Med. 2007;33:951–962
  12. Fu MJ, Tsen LY, Lee TY, Lui PW, Chan SH. Involvement of cerulospinal glutamatergic neurotransmission in fentanyl-induced muscular rigidity in the rat. Anesthesiology. 1997;87:1450–1459
  13. Lui PW, Lee TY, Chan SHH. Involvement of coerulospinal noradrenergic pathway in fentanyl-induced muscular rigidity in rats. Neurosci Lett. 1990;108:183–188
  14. Warner DO, Joyner MJ, Rehder K. Electrical activation of expiratory muscles increases with time in pentobarbital-anesthetized dogs. J Appl Physiol. 1992;72:2285–2291
  15. Bellomo R, Kellum JA, Ronco C. Defining and classifying acute renal failure: from advocacy to consensus and validation of the RIFLE criteria. Intensive Care Med. 2007;33:409–413
  16. Knaus WA, Draper EA, Wagner DP, Zimmerman JE. APACHE II: a severity of disease classification system. Crit Care Med. 1985;13:818–829
  17. Vincent JL, de Mendonça A, Cantraine F, et al. Use of the SOFA score to assess the incidence of organ dysfunction/failure in intensive care units: results of a multicentric, prospective study. Crit Care Med. 1998;26:1793–1800
  18. Aissaoui Y, Zeggwagh AA, Zekraoui A, Abidi K, Abouqal R. Validation of a behavioral pain scale in critically ill, sedated, and mechanically ventilated patients. Anesth Analg. 2005;101:1470–1476
  19. Payen JF, Bru O, Bosson JL, et al. Assessing pain in critically ill sedated patients by using a behavioral pain scale. Crit Care Med. 2001;29:2258–2263
  20. Chanques G, Jaber S, Barbotte E, et al. Impact of systematic evaluation of pain and agitation in an intensive care unit. Crit Care Med. 2006;34:1691–1699
  21. Ramsay MA, Savege TM, Simpson BR, Goodwin R. Controlled sedation with alphaxalone-alphadolone. Br Med J. 1974;2:656–659
  22. Rivers E, Nguyen B. Havstad S, et al; and Early Goal-directed Therapy Collaborative Group. Early goal-directed therapy in the treatment of severe sepsis and septic shock. N Engl J Med. 2001;345:1368–1377
  23. Malbrain ML. Different techniques to measure intraabdominal pressure (IAP): time for a critical re-appraisal. Intensive Care Med. 2004;30:357–371
  24. De Waele J, Pletinckx P, Blot S, Hoste E. Saline volume in transvesical intraabdominal pressure measurement: enough is enough. Intensive Care Med. 2006;32:455–459
  25. Malbrain ML, Deeren DH. Effect of bladder volume on measured intravesical pressure: a prospective cohort study. Crit Care. 2006;10:R98
  26. Helmy SA, Al-Attiyah RJ. The immunomodulatory effects of prolonged intravenous infusion of propofol versus midazolam in critically ill surgical patients. Anaesthesia. 2001;56:4–8
  27. Straub RH, Herrmann M, Berkmiller G, et al. Neuronal regulation of interleukin 6 secretion in murine spleen: adrenergic and opioidergic control. J Neurochem. 1997;68:1633–1639
  28. Maes M, Lin A, Kenis G, Egyed B, Bosmans E. The effects of noradrenaline and alpha-2 adrenoceptor agents on the production of monocytic products. Psychiatry Res. 2000;96:245–253
  29. Szelenyi J, Kiss JP, Vizi ES. Differential involvement of sympathetic nervous system and immune system in the modulation of TNF-alpha production by alpha2- and beta-adrenoceptors in mice. J Neuroimmunol. 2000;103:34–40
  30. Memis D, Hekimoğlu S, Vatan I, Yandim T, Yuksel M, Sut N. Effects of midazolam and dexmedetomidine on inflammatory responses and gastric intramucosal pH to sepsis, in critically ill patients. Br J Anaesth. 2007;98:550–552

 Supported by University of Trakya Research Grant No. TUBAP 666, Edirne, Turkey.

PII: S0952-8180(09)00173-1

doi: 10.1016/j.jclinane.2008.10.010

Journal of Clinical Anesthesia
Volume 21, Issue 6 , Pages 394-400 , September 2009