Sevoflurane with or without antiemetic prophylaxis of dexamethasone in spontaneously breathing patients undergoing outpatient anorectal surgery☆
Received 12 September 2007; received in revised form 3 November 2008; accepted 10 November 2008. published online 07 September 2009.
Abstract
Study Objective
To evaluate the prophylactic use of dexamethasone with sevoflurane in outpatient anorectal surgery.
Design
Randomized, controlled study.
Setting
Operating room and Postanesthesia Care Unit of a general hospital.
Patients
60 adult, ASA physical status I and II outpatients undergoing anorectal surgery.
Interventions
Patients were randomized to receive either dexamethasone 5 mg intravenously (IV; Group D; n = 30) or an equal volume of saline (Group S; n = 30) before anesthesia induction. Anesthesia was induced with propofol 2.5 mg.kg−1, fentanyl two μg.kg−1, and 2% lidocaine one mg.kg−1 followed by placement of a Laryngeal Mask Airway.
Measurements
Frequency of postoperative nausea and vomiting (PONV), visual analog scale (VAS) pain scores, and patient satisfaction were recorded.
Main Results
Frequency of PONV and VAS pain scores were significantly lower in Group D than Group S (P < 0.05). The time required for “home readiness” was significantly shorter in Group D than Group S (P < 0.05).
Conclusions
The prophylactic administration of 5 mg dexamethasone IV can reduce the frequency of PONV, lower VAS pain scores, facilitate recovery to home readiness, and improve satisfaction in outpatients undergoing anorectal surgery.
ABSTRACT