Effects of landiolol on QT interval and QT dispersion during induction of anesthesia using computerized measurement

Kaneko, Mizue; Yamaguchi, Shigeki; Hamaguchi, Shinsuke; Egawa, Hirotoshi; Fujii, Koichi; Ishikawa, Kazuyoshi; Kitajima, Toshimitsu; Minami, Junichi

doi:10.1016/j.jclinane.2008.12.027

« Previous Next »Journal of Clinical Anesthesia
Volume 21, Issue 8 , Pages 555-561, December 2009

Effects of landiolol on QT interval and QT dispersion during induction of anesthesia using computerized measurement

Mizue Kaneko, MD (Staff Anesthesiologist)
- Department of Anesthesiology, Dokkyo Medical University, School of Medicine, Tochigi 321-0293, Japan
Shigeki Yamaguchi, MD, PhD (Associate Professor)
- Department of Anesthesiology, Dokkyo Medical University, School of Medicine, Tochigi 321-0293, Japan
- Corresponding author. Tel.: +81 282 86 1111; fax: +81 282 86 0478.
Shinsuke Hamaguchi, MD, PhD (Associate Professor)
- Department of Anesthesiology, Dokkyo Medical University, School of Medicine, Tochigi 321-0293, Japan
Hirotoshi Egawa, MD, PhD (Lecturer)
- Department of Anesthesiology, Dokkyo Medical University, School of Medicine, Tochigi 321-0293, Japan
Koichi Fujii, MD, PhD (Staff Anesthesiologist)
- Department of Anesthesiology, Dokkyo Medical University, School of Medicine, Tochigi 321-0293, Japan
Kazuyoshi Ishikawa, MD (Staff Anesthesiologist)
- Department of Anesthesiology, Dokkyo Medical University, School of Medicine, Tochigi 321-0293, Japan
Toshimitsu Kitajima, MD, PhD (Professor)
- Department of Anesthesiology, Dokkyo Medical University, School of Medicine, Tochigi 321-0293, Japan
Junichi Minami, MD, PhD (Lecturer)
- Department of Hypertension and Cardiorenal Medicine, Dokkyo Medical University, School of Medicine, Tochigi 321-0293, Japan

Received 30 April 2008; received in revised form 26 December 2008; accepted 30 December 2008. published online 23 October 2009.

Abstract

Study Objective

To examine the effects of landiolol on the QT interval, rate-corrected QT (QTc) interval, QT dispersion (QTD), and rate-corrected QTD (QTcD) during tracheal intubation using computerized measurement.

Design

Randomized, double-blinded study.

Setting

Dokkyo Medical University Hospital operating room.

Patients

30 ASA physical status I patients scheduled for elective surgery.

Inventions

Patients were randomized to receive either normal saline (saline group) or landiolol (landiolol group; one-min loading infusion of 0.125 mg/kg followed by 0.04 mg/kg/min infusion). Immediately after the start of administration of saline or landiolol, anesthesia was induced with intravenous (IV) fentanyl two μg/kg, propofol 1.5 mg/kg, and vecuronium 0.1 mg/kg. Six minutes after administration of saline or landiolol, tracheal intubation was performed within 20 seconds.

Measurements

Mean arterial pressure (MAP), RR interval, QT interval, QTc interval, QTD, and QTcD were consecutively recorded during the induction.

Main Results

There was no significant difference in MAP between groups during the study. RR interval in the landiolol group was significantly longer than in the saline group from two minutes after the start of the landiolol infusion to the end of the study. The QT interval in the landiolol group was significantly shorter than in the saline group from start of the infusion to 4 minutes after tracheal intubation. The QTc interval, QTD, and QTcD in the landiolol group were significantly shorter than those in the saline group from immediately after tracheal intubation to the end of study.

Conclusion

A bolus of landiolol 0.125 mg/kg followed by an infusion of landiolol 0.04 mg/kg/min may reduce the risk of cardiac arrhythmias during induction of anesthesia.

Keywords: Tracheal intubation, QT interval, Rate-corrected QT interval, QT dispersion, Rate-corrected QT dispersion, Landiolol