Journal of Clinical Anesthesia
Volume 22, Issue 1 , Pages 22-28 , February 2010

Nitric oxide index is not a predictor of cognitive dysfunction following laparotomy

  • Ciaran Twomey, FCARCSI (Lecturer)

      Affiliations

    • Department of Anaesthesia and Intensive Care Medicine, Cork University Hospital and University College Cork, Ireland
    • Corresponding Author InformationCorresponding author. Department of Anesthesia, University of Alberta Hospital, Edmonton, AB T6G 2G3, Canada. Tel.: +1 780 407 8861; fax: +1 780 407 3200.
    • ,
  • Mark Corrigan, MRCSI (Specialist Registrar)

      Affiliations

    • Department of Surgery, Cork University Hospital and University College, Cork, Ireland
    • ,
  • Crina Burlacu, FCARCSI (Specialist Registrar)

      Affiliations

    • Department of Anaesthesia and Intensive Care Medicine, Cork University Hospital and University College Cork, Ireland
    • ,
  • Mark Butler, MSc (Senior Biochemist)

      Affiliations

    • Department of Anaesthesia and Intensive Care Medicine, Cork University Hospital and University College Cork, Ireland
    • ,
  • Gabriella Iohom, PhD (Specialist Registrar)

      Affiliations

    • Department of Anaesthesia and Intensive Care Medicine, Cork University Hospital and University College Cork, Ireland
    • ,
  • George Shorten, MD, PhD, FCARCSI (Professor)

      Affiliations

    • Department of Anaesthesia and Intensive Care Medicine, Cork University Hospital and University College Cork, Ireland

Received 24 January 2008 ,Revised 5 February 2009 ,Accepted 11 February 2009.

References 

  1. Johnson T, Monk T, Rasmussen LS, et al. Postoperative cognitive dysfunction in middle-aged patients. Anesthesiology. 2002;96:1351–1357
  2. Moller JT, Cluitmans P, Rasmussen LS, et al. Long-term postoperative cognitive dysfunction in the elderly ISPOCD1 study. ISPOCD investigators. International Study of Post-Operative Cognitive Dysfunction. Lancet. 1998;351(9106):857–861
  3. Dodds C, Allison J. Postoperative cognitive deficit in the elderly surgical patient. Br J Anaesth. 1998;81:449–462
  4. Lipowski ZJ. Delirium in the elderly patient. N Engl J Med. 1989;320:578–582
  5. Liu LL, Leung JM. Predicting adverse postoperative outcomes in patients aged 80 years or older. J Am Geriatr Soc. 2000;48:405–412
  6. Iohom G, Szarvas S, Larney V, et al. Perioperative plasma concentrations of stable nitric oxide products are predictive of cognitive dysfunction after laparoscopic cholecystectomy. Anesth Analg. 2004;99:1245–1252
  7. Narain PK, DeMaria EJ. Initial results of a prospective trial of outpatient laparoscopic cholecystectomy. Surg Endosc. 1997;11:1091–1094
  8. Kehlet H. Manipulation of the metabolic response in clinical practice. World J Surg. 2000;24:690–695
  9. Geller DA, Nussler AK, Di Silvio M, et al. Cytokines, endotoxin, and glucocorticoids regulate the expression of inducible nitric oxide synthase in hepatocytes. Proc Natl Acad Sci USA. 1993;90:522–526
  10. Murkin JM, Newman SP, Stump DA, Blumenthal JA. Statement of consensus on assessment of neurobehavioral outcomes after cardiac surgery. Ann Thorac Surg. 1995;59:1289–1295
  11. Zigmond AS, Snaith RP. The hospital anxiety and depression scale. Acta Psychiatr Scand. 1983;67:361–370
  12. Broadbent DE, Cooper PF, FitzGerald P, Parkes KR. The Cognitive Failures Questionnaire (CFQ) and its correlates. Br J Clin Psychol. 1982;21(Pt 1):1–16
  13. Jacobson NS, Truax P. Clinical significance: a statistical approach to defining meaningful change in psychotherapy research. J Consult Clin Psychol. 1991;59:12–19
  14. Linstedt U, Meyer O, Kropp P, Berkau A, Tapp E, Zenz M. Serum concentration of S-100 protein in assessment of cognitive dysfunction after general anesthesia in different types of surgery. Acta Anaesthesiol Scand. 2002;46:384–389
  15. Harmon DC, Ghori KG, Eustace NP, O'Callaghan SJ, O'Donnell AP, Shorten GD. Aprotinin decreases the incidence of cognitive deficit following CABG and cardiopulmonary bypass: a pilot randomized controlled study. Can J Anaesth. 2004;51:1002–1009
  16. Rasmussen LS, Larsen K, Houx P, et al. ISPOCD group The International Study of Postoperative Cognitive Dysfunction. The assessment of postoperative cognitive function. Acta Anaesthesiol Scand. 2001;45:275–289
  17. Rasmussen LS. Defining postoperative cognitive dysfunction. Eur J Anaesthesiol. 1998;15:761–764
  18. Rasmussen LS, Siersma VD ISPOCD Group. Postoperative cognitive dysfunction: true deterioration versus random variation. Acta Anaesthesiol Scand. 2004;48:1137–1143
  19. Szabó C. Physiological and pathophysiological roles of nitric oxide in the central nervous system. Brain Res Bull. 1996;41:131–141
  20. Laffey JG, Boylan JF, Cheng DC. The systemic inflammatory response to cardiac surgery: implications for the anesthesiologist. Anesthesiology. 2002;97:215–252
  21. Granger DL, Anstey NM, Miller WC, Weinberg JB. Measuring nitric oxide production in human clinical studies. Methods Enzymol. 1999;301:49–61
  22. Almeida A, Almeida J, Bolaños JP, Moncada S. Different responses of astrocytes and neurons to nitric oxide: the role of glycolytically generated ATP in astrocyte protection. Proc Natl Acad Sci USA. 2001;98:15294–15299
  23. Yamauchi M, Omote K, Ninomiya T. Direct evidence for the role of nitric oxide on the glutamate-induced neuronal death in cultured cortical neurons. Brain Res. 1998;780:253–259
  24. Stewart VC, Heales SJ. Nitric oxide-induced mitochondrial dysfunction: implications for neurodegeneration. Free Radic Biol Med. 2003;34:287–303
  25. Szabó C, Dawson VL. Role of poly(ADP-ribose) synthetase in inflammation and ischaemia-reperfusion. Trends Pharmacol Sci. 1998;19:287–298
  26. Clark RS, Kochanek PM, Obrist WD, et al. Cerebrospinal fluid and plasma nitrite and nitrate concentrations after head injury in humans. Crit Care Med. 1996;24:1243–1251

PII: S0952-8180(09)00340-7

doi: 10.1016/j.jclinane.2009.02.011

Journal of Clinical Anesthesia
Volume 22, Issue 1 , Pages 22-28 , February 2010

Article Tools