Journal of Clinical Anesthesia
Volume 22, Issue 1 , Pages 35-40 , February 2010

A comparative study of dexmedetomidine with midazolam and midazolam alone for sedation during elective awake fiberoptic intubation

  • Sergio D. Bergese, MD (Assistant Professor, Director)

      Affiliations

    • Department of Anesthesiology, The Ohio State University, Columbus, OH 43210, USA
    • Department of Neurosurgery, The Ohio State University, Columbus, OH 43210, USA
    • ,
  • Stephen Patrick Bender, MD (Resident)

      Affiliations

    • Department of Anesthesiology, The Ohio State University, Columbus, OH 43210, USA
    • ,
  • Thomas D. McSweeney, BS, CLT (Clinical Research Coordinator)

      Affiliations

    • Department of Anesthesiology, The Ohio State University, Columbus, OH 43210, USA
    • ,
  • Soledad Fernandez, PhD (Assistant Senior Consulting Research Statistician)

      Affiliations

    • Center for Biostatistics, The Ohio State University, Columbus, OH 43210, USA
    • ,
  • Roger Dzwonczyk, MS (Clinical Associate Professor)

      Affiliations

    • Department of Anesthesiology, The Ohio State University, Columbus, OH 43210, USA
    • Corresponding Author InformationCorresponding author.
    • ,
  • Kevin Sage, DO (Resident)

      Affiliations

    • Department of Anesthesiology, The Ohio State University, Columbus, OH 43210, USA

Received 29 January 2008 ,Revised 17 February 2009 ,Accepted 26 February 2009.

References 

  1. Rosenblatt WH. Airway management. In:  Barash PG,  Cullen BF,  Stoelting RK, et al. editor. Clinical Anesthesia. 4th ed.. Philadelphia: Lippincott Williams & Wilkins; 2001;p. 595–638
  2. Ovassapian A. In: Fiberoptic endoscopy and the difficult airway. 2nd ed.. Philadelphia: Lippincott-Raven Publishers; 1996;p. 61–69
  3. Bailey PL, Pace NL, Ashburn MA, Moll JW, East KA, Stanley TH. Frequent hypoxemia and apnea after sedation with midazolam and fentanyl. Anesthesiology. 1990;73:826–830
  4. Kamibayashi T, Maze M. Clinical uses of alpha2-adrenergic agonists. Anesthesiology. 2000;93:1345–1349
  5. Ebert TJ, Hall JE, Barney JA, Uhrich TD, Colinco MD. The effects of increasing plasma concentrations of dexmedetomidine in humans. Anesthesiology. 2000;93:382–394
  6. Venn RM, Hell J, Grounds RM. Respiratory effects of dexmedetomidine in the surgical subject requiring intensive care. Crit Care Med. 2000;4:302–308
  7. Grant SA, Breslin DS, MacLeod DB, Gleason D, Martin G. Dexmedetomidine infusion for sedation during fiberoptic intubation: a report of three cases. J Clin Anesth. 2004;16:124–126
  8. Chernik DA, Gillings D, Laine H, et al. Validity and reliability of the Observer's Assessment of Alertness/Sedation Scale: study with intravenous midazolam. J Clin Psychopharmacol. 1990;10:244–251
  9. Ambuel B, Hamlett KW, Marx CM, Blumer JL. Assessing distress in pediatric intensive care environments: the COMFORT scale. J Pediatr Psychol. 1992;17:95–109
  10. Avitsian R, Lin J, Lotto M, Ebrahim Z. Dexmedetomidine and awake fiberoptic intubation for possible cervical spine myelopathy. J Neurosurg Anesthesiol. 2005;17:97–99
  11. Ramsay MA, Luterman DL. Dexmedetomidine as a total intravenous anesthetic agent. Anesthesiology. 2004;101:787–790
  12. Bhana N, Goa KL, McClellan KJ. Dexmedetomidine. Drugs. 2000;59:263–268
  13. Ebert T, Maze M. Dexmedetomidine: another arrow for the clinician's quiver. Anesthesiology. 2004;101:568–570
  14. Bloor BC, Ward DS, Belleville JP, Mervyn M. Effects of intravenous dexmedetomidine in humans II. Hemodynamic changes. Anesthesiology. 1992;77:1134–1142
  15. Jorden VS, Pousman RM, Sanfor MM, Thorborg PA, Hutchens MP. Dexmedetomidine overdose in the perioperative setting. Ann Pharmacother. 2004;38:803–807
  16. Venn RM, Grounds RM. Comparison between dexmedetomidine and propofol for sedation in the intensive care unit: patient and clinician perceptions. Br J Anaesth. 2001;87:684–690
  17. Peden CJ, Cloote AH, Stratford N, Prys-Roberts C. The effect of intravenous dexmedetomidine premedication on the dose requirement of propofol to induce loss of consciousness in patients receiving alfentanil. Anaesthesia. 2001;56:408–413
  18. Porro GB, Garoni S, Parente F, Lazzaroni M. Midazolam versus diazepam as premedication for upper gastrointestinal endoscopy: a randomized, double-blind, crossover study. Gastroint Endosc. 1988;34:252–254
  19. Hall JE, Uhrich TD, Barney JA, Arain SR, Ebert TJ. Sedative, amnestic, and analgesic properties of small dose dexmedetomidine infusions. Anesth Analg. 2000;90:699–705
  20. Ustun Y, Gunduz M, Erdogan O, Bendlidayi ME. Dexmedetomidine versus midazolam in outpatient third molar surgery. J Oral Maxillofac Surg. 2006;64:1353–1358

☆ Funded by a grant from Hospira Inc., Lake Forest, IL, USA.

PII: S0952-8180(09)00359-6

doi: 10.1016/j.jclinane.2009.02.016

Journal of Clinical Anesthesia
Volume 22, Issue 1 , Pages 35-40 , February 2010

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