Comparison of 50 μg and 25 μg doses of intrathecal morphine on postoperative analgesic requirements in patients undergoing transurethral resection of the prostate with intrathecal anesthesia

Duman, Ates; Apiliogullari, Seza; Balasar, Mehmet; Gürbüz, Recai; Karcioglu, Murat

doi:10.1016/j.jclinane.2009.09.006

« Previous Next »Journal of Clinical Anesthesia
Volume 22, Issue 5 , Pages 329-333, August 2010

Comparison of 50 μg and 25 μg doses of intrathecal morphine on postoperative analgesic requirements in patients undergoing transurethral resection of the prostate with intrathecal anesthesia

Ates Duman, MD (Associate Professor of Anesthesiology)
- Selcuklu Medical Faculty, Department of Anesthesiology, Selcuk University, Konya, Turkey
Seza Apiliogullari, MD (Assistant Professor of Anesthesiology)
- Selcuklu Medical Faculty, Department of Anesthesiology, Selcuk University, Konya, Turkey
- Corresponding author. Department of Anesthesiology, Selcuklu Medical Faculty, Selcuk University, Konya, Turkey 42070. Tel.: +90 505 488 7014; fax: +90 332 241 0062.
Mehmet Balasar, MD (Staff Urologist)
- Department of Urology, Konya Hospital, Konya, Turkey
Recai Gürbüz, MD (Professor of Urology)
- Department of Urology, Meram Medical Faculty, Selcuk University, Konya, Turkey
Murat Karcioglu, MD (Assistant Professor of Anesthesiology)
- Department of Anesthesiology and Intensive Care, Medical Faculty, Mustafa Kemal University, Hatay, Turkey

Received 11 July 2008; received in revised form 15 September 2009; accepted 26 September 2009.

Abstract

Study Objective

To compare the efficacy of 50 μg and 25 μg doses of intrathecal morphine on postoperative pain in patients undergoing transurethral resection of the prostate (TURP) with low-dose bupivacaine.

Design

Randomized, double-blinded study.

Setting

Konya Hospital.

Patients

70 ASA physical status I, II, and III patients.

Interventions

Patients were randomized to two groups: Group A patients received 5 mg of 0.5% hyperbaric bupivacaine (one mL) and 50 μg of morphine (0.5 mL). Group B patients received 5 mg of 0.5% hyperbaric bupivacaine (one mL) and 25 μg of morphine (0.5 mL).

Measurements

Postoperative pain scores, patient and surgeon satisfaction, and side effects such as emesis, pruritus, and respiratory depression, were recorded.

Main Results

Postoperative pain characteristics were similar between the two groups. Frequency of emesis was similar between the groups, while pruritus was significantly higher in Group A. No antipruritic medication was required in any patient. Patient and surgeon satisfaction was evaluated as good or excellent in both groups.